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Its considered experimental, and its safety and efficacy profiles have not been firmly established through large-scale clinical trials
Controlled freezing studies of recombinant hGH demonstrated that insoluble particulate aggregation increases sharply with cooling rate, with pH 7.4 formulations producing markedly more light-scattering particulates than pH 7.8 formulations after freeze-thaw (Eckhardt, Oeswein & Bewley, 1991)
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In 2024, Koniver was sanctioned by South Carolina public-health officials who found, among other things, that hed failed to maintain his registration with the Drug Enforcement Administration while prescribing controlled substances, and that hed neglected to check patient vital signs before administering ketamine
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