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Experimental studies have demonstrated measurable increases in circulating growth hormone and downstream IGF-1 signaling in controlled settings, with preserved natural GH pulsatility and no observed pituitary desensitization at standard research doses [2]

2019-June-13 2019;10(407)doi:10.3389/fpsyt.2019.00407 Sugarman MA, Loree AM, Baltes BB, Grekin ER, Kirsch I

PubMed MDPI 4

Stimulation testing by endocrinologists can assess pituitary reserve, helping determine if Sermorelin represents appropriate therapy or if synthetic growth hormone replacement proves necessary

The one person who could clear that up wont

Epub 2022 Jun 9