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Retatrutide, a not endogenously occurring peptide, stimulated the glucagon receptor (GCGR), the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR), and the glucagon-like peptide-1 receptor (GLP-1R) in cell cultures

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This doesn't mean GLP-1 therapy will fail, but it may suggest the need for higher doses, longer titration periods, or consideration of combination therapies like tirzepatide (dual GIP/GLP-1 receptor agonist) that engage additional pathways

Neuron 2021;109:461-72.ArticlePubMed 101