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Cell subpopulations with high OXPHOS activity consistently exhibit greater drug resistance, suggesting that mitochondrial metabolic heterogeneity may serve as a critical biomarker for resistance stratification and therapeutic classification [66]
Singh, B
The cells were then switched to DMEM differentiation medium and treated with 1000 g/mL of L-carnitine for an additional 24 h
There is little clinical guidance on this, so pharmacists must prioritise patient safety and, since there is no validated dose equivalence, the safest approach is to start the new medication its lowest available dose then titrate gradually per standard schedule
Vermeulen RCW, Scholte HR
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