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If you have an underlying cardiovascular condition

BMC Genomics 6, 166

Redefining Clostridioides difficile infection antibiotic response and clinical outcomes

It may protect L02 cells from acetaminophen-induced damage by activating the Keap1-Nrf2 antioxidant defense mechanism

High blood pressure Some animal research indicates that chanca piedra may help relax the blood vessels, which could lead to reductions in blood pressure ( Yet, one human study noted a slight, but not clinically significant, increase in blood pressure in participants while taking chanca piedra for 12 weeks