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In addition, Orai1, a Ca 2+ channel, has emerged as a key regulator of reactive astrocytes by controlling the synthesis and release of a broad range of proinflammatory mediators 113

Inflammation and immune modulation Chronic inflammation and immune dysregulation are central to the pathogenesis and progression of MASLD, 115 particularly during the transition from simple steatosis to MASH

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It is referenced here strictly as a research and educational topic, for in-vitro use only