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All data are expressed as the mean SD from at least three biological replicates, and comparisons between the two groups were performed with a nonparametric method (MannWhitney U test)

Megalin is expressed along the apical aspect of proximal tubules, where it is responsible for hepatocyte-derived AGT reabsorption and its homeostasis in kidney

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Patents cover coformulations with SGLT2 inhibitors, incretin combinations, and thyroid receptor agonist pairings [25, 26], reflecting the clinical reality that many patients will benefit from multi-mechanism approaches

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