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In the intracellular side, a sharp kink located in the conserved Pro 6.47b -X-X-Gly 6.50b motif pivoted the intracellular tip of TM6 to move outwards by 19.3 (measured by C atom of K344 6.35b ), slightly higher than that seen with the GCGGCGRG s (17.7 ) 4

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After this period, TEA was evaporated and 150 mg of PURE G4 (0.019 mmol) in DMF anhydrous (0.75 mL) and 0.070 mL of TEA (0.502 mmol) were added and allowed to react overnight

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However, when oral supplements like high doses of vitamin C are consumed, the body cannot absorb them at those levels

At 80 h post-administration, the survival rate was 90% for wild-type mice but dropped to 0% for hepsin / mice (Fig