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To determine if increased ROS was responsible for the chaining and restriction in BMDMs, we treated cells with 20 M hydrogen peroxide (H 2 O 2 )

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However, it is not safe in the regulatory sense the peptide is not FDA-approved for human use, long-term safety data do not exist, and the non-selective melanocortin receptor activation produces predictable systemic effects including nausea (4060% of users), flushing, appetite suppression, and sexual side effects