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High levels of leptin, which are common in individuals with obesity due to leptin resistance, fail to properly signal satiety, leading to continued food intake and reduced energy expenditure [32]

What to Do If You Miss a Dose Tirzepatide has a 5-day half-life, which means blood levels decline gradually after a missed dose

This carefully structured approach helps minimize side effects while maximizing weight management benefits

It has also contributed to strengthening regulatory capacity in low- and middle-income countries by providing shared frameworks, training, and guidance.

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