Saffron at high doses has been associated with GI upset in some people, though the doses used in these studies werent flagged for safety concerns
Mol Cell Endocrinol 297:3440 Mukai E, Fujimoto S, Sato H, Oneyama C, Kominato R, Sato Y, Sasaki M, Nishi Y, Okada M, Inagaki N (2011) Exendin-4 suppresses Src activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner
Retatrutide does not desensitize the same way
I still should be able to take this on
Funding The research in the authors laboratory was supported by the National Natural Science Foundation of China Grant (No.8217140592, No.81673671) and Special National Key Research and Development Plan (No.2016YFC1306305 J-DX)
If you have a Medicare health plan, consider other benefits that could help you with weight management, such as nutrition counseling