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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs
Inform your healthcare provider about your diet, including any fortified foods you consume, to ensure you are getting the right amount of B12
46% placebo) and no growth suppression signal [10]
Key Insight: With no energy improvements by week 4, bloodwork can help assess whether NNMT is being effectively inhibited
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