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After a 90-min incubation at room temperature, FP signal was measured using a PheraStar plate reader (BMG Labtech) with an FP module (excitation: 485 nm, emission: 520 nm (S/P))

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5-Oxoprolinase deficiency Disease name 5-Oxoprolinase deficiency (OMIM 260005) Definition and diagnostic criteria 5-Oxoprolinase deficiency is a very rare autosomal recessive disease characterized by 5-oxoprolinuria and very heterogeneous clinical presentation (renal stone formation, enterocolitis, mental retardation, neonatal hypoglycemia, microcytic anemia and microcephaly)

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