Recovery from exercise often improves during this phase
The STEP-1 extension (Wilding 2022) followed 1,961 patients for 52 weeks after discontinuing semaglutide 2.4 mg
GLP-1 agonists are actually being studied for treating liver conditions like metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) because they reduce fat in the liver, improve enzymes, and may slow disease progression
Consistently, the DHODH inhibitor Brequinar specifically promotes ferroptosis in GPX4-low-expressing cells by reducing mitochondrial CoQ10H 2 levels (110)
But for selected patients, thoughtful hormone evaluation may be part of a broader plan to support sleep, body composition, sexual health, energy, bone, mood, and quality of life
[1,2] When overweight categories are included, the burden becomes even more striking: since 2022, approximately 40% of Canadian men and 30% of women are classified as overweight, meaning that nearly three in four men and two in three women fall within BMI ranges associated with increased health risk