Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism
Additionally, there are both oral and injectable options, with injectable options that are dosed daily or weekly
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Larger, controlled studies are needed to validate these findings and assess their broader clinical applicability
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Haq S, Grondin J, Banskota S, et al