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53 Hyperferritinemia and hemoglobinopathy have been reported to accelerate the progression of COVID-19 infection

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In this sense, several diseases or conditions or genetic disorders that are predisposing to eryptosis, including deficiency in glucose-6-phosphate dehydrogenase, sickle cell anemia, beta-thalassemia trait, iron insufficiency or deficiency of carriers like GLUT1, AE1 are known to provide a certain degree of defense against a severe malarial course [230, 404]

However, erythrocytes are also a functional part of this transport mechanism, as they contain the enzyme carbonic anhydrase and the most abundant erythrocyte membrane protein, anion exchanger 1 (AE1, Band 3 protein, SLC4A1)

Systems were equilibrated in isothermal-isobaric conditions (NPT) using the Berendsen barostat 51 with a target pressure of 1 atm, the Langevin thermostat 52 with a target temperature of 310 K, along with a low damping factor of 1 ps 1 and an integration time step of 2 fs

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