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First, optimal dosing in humans remains undefined, with current practice based primarily on extrapolation from animal studies and anecdotal clinical experience rather than formal dose-finding studies
This unique sequence allows DSIP to be highly resistant to degradation, making it stable at room temperature and capable of crossing the blood-brain barrier
although both shorter and longer linkers have been reported, it still seems empirical and optimization is required for each pair of ligase and target protein, since it is likely that optimal linker identity will vary for different proteins targeted
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It seemed to have positive effects for many people, so I decided to try it
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