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The analysis captured changes in risk factors with semaglutide 1 mg and placebo, including HbA 1c , SBP, BMI, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, eGFR, and hemoglobin, as well as severe hypoglycemic event rates, with data taken from the FLOW clinical trial for the first 3 years of the analysis [23, 24]
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Importantly, lean tissue has a higher metabolic rate than adipose tissue, and its preservation is critical for sustaining metabolic health, physical function, and long-term weight maintenance