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The following is just part of the guidance that BANT recommend on all GLP-1 weight-loss medications, which includes Wegovy, Ozempic and Mounjaro

Patients with diabetes or obesity may have baseline differences in immune response compared to the general population, independent of semaglutide use

The key difference lies in receptor targeting: Semaglutide GLP-1 receptor only Tirzepatide GLP-1 + GIP receptors Retatrutide GLP-1 + GIP + glucagon receptors The addition of glucagon receptor activity introduces a potential energy-expenditure component compared with GLP-1-only compounds

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