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GLP-1 receptor agonists enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety through central nervous system pathways

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Anaesthetic management strategies may include: Point-of-care gastric ultrasound to assess stomach contents before proceeding with anaesthesia Use of rapid sequence induction techniques with cricoid pressure to minimise aspiration risk Clear-fluid diet for 24 hours before surgery in higher-risk patients Consideration of regional or local anaesthesia alternatives when appropriate In some cases, postponement of elective surgery if significant gastric contents are identified There is no evidence that GLP-1 medications affect the efficacy of anaesthetic drugs, alter consciousness levels, or interfere with post-operative recovery in ways unrelated to aspiration risk