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Based on available Phase 2 data, both agents share a side-effect profile broadly consistent with other medicines acting on metabolic hormone pathways, though the triple-agonist mechanism of retatrutide introduces some additional considerations
Feinberg C, Housley NA, Bhatt DL, et al
Acute renal tubular necrosis and impaired renal function due to acetaminophen nephrotoxicity are manifested by increased serum creatinine levels (Murad et al
Together with ceramides and fatty acids, they play a vital role in having a healthy skin barrier and keeping the skin hydrated
Observed Side Effects (From Clinical Trials) In the Lancet 2021 Phase 2 trial (n=706), at the highest 4.5 mg/week dose, 88% of participants reported at least one side effect and 63% reported a GI-specific event
Higuchi Y
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