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Retatrutide is an investigational triple hormone receptor agonist that activates GLP-1, GIP, and glucagon receptors

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These receptors promote downstream pathways that are important for appetite regulation, insulin sensitivity, and metabolism, among other benefits, and so lead to improvements in weight and metabolic health. Ali adds that the stimulation slows stomach emptying, increasing the chance a patient is satiated longer (and therefore eats less)

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The effectiveness of these medications can vary from person to person, and how you respond to these medications may differ based on factors such as genetics