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others stay on a lower maintenance dose

No difference in adverse events was observed with the SGLT2i combination in the respective Harmony Outcomes and AMPLITUDE-O post-hoc analyses

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Common appetite-related changes include reduced hunger between meals, feeling full faster during meals, nausea or discomfort after rich or fatty foods, and longer stretches between feeling hungry

Many struggle to lose weight or keep it off through these approaches alone

The STEP trials showed continued weight loss improvement at higher doses, with the dose-response relationship remaining positive through 2.4 mg