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Biochem Biophys Res Commun 83:10931098

FIGURE 2 An umbrella review of meta-analyses of observational studies archived in the PubMed and Embase databases that included 1,175,720 women who had used antidepressants during pregnancy reported that the use of SSRIs during pregnancy was associated with a 43% increase in the risk of preterm labor, a 43% increased risk of respiratory distress, a 33% associated with respiratory distress, a 26% increased risk of cardiovascular malformations, and a decrease in 1-min Apgar scores (Biffi et al., 2020)

Li ZY, Zhang N, Wen S, Zhang J, Sun XL, Fan XM et al (2017) Decreased glucagon-like peptide-1 correlates with abdominal pain in patients with constipation-predominant irritable bowel syndrome

It can miss: impurities with similar retention times, peptides that do not absorb well at the detector wavelength, and endotoxin contamination, which requires a separate LAL or recombinant factor C assay