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(4) Both Ipamorelin & Sermorelin are posited to produce action on the pituitary gland

First, since HSL is apparently the primary diacylglycerol lipase in adipose tissue, the accumulation of diacylglycerol in WAT of HSL null mice might interfere with normal adipocyte differentiation or function through the activation of protein kinase C family members and their downstream targets, which are known to affect cell proliferation, apoptosis, and differentiation (Figure 2A)

However, if you notice hardening or worsening swelling that gets worse over weeks, this could be a sign of localized hypersensitivity and/or even a secondary bacterial infection

Greger is a physician, New York Times Best-Selling author, and internationally recognized speaker on nutrition, food safety, and public health issues