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The pivotal STEP trials for semaglutide and SURMOUNT trials for tirzepatide included thousands of participants with monitoring for suicidal ideation using standardized tools such as the Columbia-Suicide Severity Rating Scale (C-SSRS), and did not demonstrate elevated rates compared to placebo groups
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Semaglutide typically supports weight loss
Both have different doses and titration schedules
Regular followup and adjustments are essential, and providers should set realistic expectations with patients from the outset
Kr BFC, Moldovan S, Nguyen TH, Watt PC, Walsh J, Gingerich R
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