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Neither does any treatment come with a guarantee of weight loss results
Steroids promote weight gain and increase appetite through metabolic and hormonal pathways, while semaglutide suppresses appetite and supports weight loss
But the timing of that weekly injection still matters, and the reasoning behind it is worth understanding rather than simply following a rule without knowing why
Rarer but more serious risks include pancreatitis and thyroid tumours, so patient selection and follow-up matter
Abbreviations BBB: Blood-brain barrier CGRP: Calcitonin gene-related peptide CM: Chronic migraine CNS: Central nervous system CSD: Cortical spreading depression DMEM: Dulbeccos modified Eagles medium FBS: Foetal bovine serum GLP-1R: Glucagon-like peptide-1 receptor IGF-1: Insulin-like growth factor-1 IS: Inflammatory soup LPS: Lipopolysaccharide NTG: Nitroglycerin PI3K: Phosphoinositide 3-kinase PKA: Protein kinase A PMSF: Phenylmethylsulfonyl fluoride RT: Room temperature TNC: Trigeminal nucleus caudalis References May A, Schulte LH (2016) Chronic migraine: risk factors, mechanisms and treatment
Rhodamine-labeled GCs (1525 m in diameter) were used for electrophysiological recording within 23 h after separation
