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Tenascin-X deficiency is associated with EhlersDanlos syndrome
That single distinction, downstream fragment versus upstream signal, drives every other difference between them: what happens to your IGF-1, how strong the human evidence is, and who each one fits
The effects are not permanent
That is the whole story, start to finish: a stubborn idea from 1975, a researcher who spent his life on it, a compound that healed everything in rats, a human trial whose result nobody saw for twenty years, a molecule no company can own so no company will finish testing, and a stack of the most basic questions is it safe, at what dose, made by whom, and how does it actually work that still have no answers
Immunodetection was carried out using primary antibodies: Rat anti-BrdU (BU1/75 (ICR1) (Abcam, Cat#ab6326)) at a dilution of 1:20 in BlockAid Blocking Solution (Invitrogen, Cat#B10710) for CldU detection, and Mouse anti-BrdU (Clone B44) (BD Bioscience, Cat#347580) at a dilution of 1:5 in Blocking Buffer for IdU detection
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