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The LEADER trial demonstrated a significant reduction in the rate of cardiovascular death, nonfatal MI, or nonfatal stroke in patients with type II diabetes treated with liraglutide
How dosing and titration usually work GLP-1s are typically started low and increased slowly to improve tolerance
The reason has to do with the sneaky way it suppresses vasopressin, the hormone that tells our kidneys to hold on to water
[8] [1] Rotating injection sites with each dose, as recommended by the American Association of Clinical Endocrinology (AACE) and the American Diabetes Association, helps prevent lipohypertrophy (fatty lumps) and reduces localized tenderness from repeated injections in the same area
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