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Once glutathione molecules reach the gut, they are surrounded by enzymes called gamma-glutamyl transpeptidases, which convert them into relatively ineffective compounds

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The former represents a predictable pharmacokinetic principle that enables effective once-weekly dosing, while the latter would suggest inadequate elimination leading to toxicity

doi: 10.1016/j.jacc.2024.05.065 31 HullonDSubehGKVolkovaYJaniecKTrachAMnevetsR