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The addition of B6, B12, glycine, or niacinamide creates a different formulation that some compounders have argued allows continued preparation under different regulatory provisions
Acidification will increase excretion, while alkalinization will decrease it
The STEP (Semaglutide Treatment Effect in People with obesity) clinical trial program provided the primary evidence base, showing continued efficacy without significant safety concerns emerging over extended use
On top of that, NBJ recently reported from a survey in October 2024 that 46% of GLP-1 agonist users take supplements daily
Presented for research literature review only Carland JE et al
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