doi: 10.1161/CIRCULATIONAHA.118.033552
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Semaglutide: GLP-1 Only Semaglutide mimics glucagon-like peptide-1, a gut hormone that slows gastric emptying, reduces appetite through hypothalamic signaling, enhances insulin secretion, and suppresses glucagon release
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The clinical impact of this effect varies between individuals, and while studies of subcutaneous GLP-1 receptor agonists have generally been reassuring, caution is still advised, particularly as levothyroxine has a narrow therapeutic index