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The drugs lack of efficacy in this context does not preclude its potential utility in the broader, more heterogeneous population of older adults experiencing cognitive decline, where vascular and metabolic factors frequently play a major role
The LEADER trial [17] was the first with a long-acting agonist (liraglutide provides a varying but relevant 24-hour exposure)
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10.1111/obr.13717 42 NathanD
Heres where things get really serious: Chronic, high-dose use of any IGF-1 analog carries theoretical risk of organ growth (visceral tissue, heart, intestines) and potential contribution to tumor growth in individuals with existing but undiagnosed cancers
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