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the Real World 0:16:31 The through-line of the episode: drugs behave differently outside controlled settings
Patience here protects potency
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Wegovy standalone trials The STEP 1 trial (published in NEJM, 2021) enrolled 1,961 adults without type 2 diabetes and found that semaglutide 2.4 mg produced 14.9% average weight loss over 68 weeks, compared with 2.4% on placebo
Studies show that semaglutides work fairly fast: with no change in eating habits, patients lose 2% of their weight in 4 weeks, significantly more with calorie restrictions, and (to everyones delight) weight loss begins with dreaded belly fat, which had accumulated because of excess insulin (the tummy is lipophilic, it loves fat)
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