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52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA
We start with the dominant symptom, monitor response, and add therapies in a staged fashion, always weighing metabolic and oncologic risks
This is normal, not a failed treatment
Most importantly, it highlights that retatrutide remains an investigational therapy, with ongoing research shaping its future role
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