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Retatrutide is investigated as a unimolecular agonist that engages three complementary incretin and glucagon pathways simultaneously, with research interest in body composition, hepatic lipid metabolism, glycemic endpoints, and energy expenditure in obesity and metabolic disease models

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These findings identify a neural circuit through which small-molecule GLP1RAs modulate reward processing, with implications for the treatment of substance-use disorder and binge eating

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doi: 10.1016/j.intimp.2018.04.042 166 VenugopalNAcharyaPZareiMTalahalliRR