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Melanotan 1 (afamelanotide) is MC1R-preferential, so it centers on skin pigmentation and photoprotection without the same MC4R-mediated sexual and appetite effects
10.1016/j.pbb.2007.12.018 Pharmacol
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They can also have important effects on immune and metabolic health, broadening their potential therapeutic uses to include prevention or treatment of such diverse disorders as allergies, infections, skin disorders, heart disease, type 2 diabetes, obesity, depression, and neurological disorders (Yu 2020
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