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The long-term follow-up of the UKPDS study showed a significant 24% reduction in microvascular disease and a 15% reduction in macrovascular complications, such as myocardial infarction, along with a 13% reduction in all-cause mortality [6]
Limitations include small cohorts, short follow-up, heterogeneous peptide types and doses, and mixed endpoints
Based on the previous discussion, administration of antioxidants or Nrf2 inducers are potential viable therapies for viral-induced diseases, like respiratory infections and infections associated with reduced cellular antioxidant capacity (Komaravelli and Casola, 2014)
By improving cerebral blood flow, GLP-1s enhance glucose and oxygen delivery, support mitochondrial ATP production, and reduce energy insufficiency that promotes synaptic dysfunction, impaired protein clearance, and neuroinflammation [5]
and the mean HDL-C was 1.38 0.32 mmol/L
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