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& Stubbs, M
Arch Biochem Biophys 1967
This creates a challenging bottleneck for formulators who need to deliver a functional dose to achieve the desired output
Critically, the retatrutide data also showed that weight loss had not plateaued by the end of the trial period
Unlike GSDMD, this modification does not affect GSDME cleavage by Caspase-3 but promotes the dissociation of the cleaved N-terminal and C-terminal fragments, thereby releasing active GSDME-NT [112]
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