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As subjects were included when either treatment combination was initiated, any previous use of metformin, GLP-1 RA or DPP-4is alone or in combination with any other glucose-lowering drug was allowed
Participants received semaglutide 2.4 mg weekly or placebo for 68 weeks with lifestyle intervention
Published literature can inform receptor and pathway context, but it should not become a claim about a research-use-only material
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All other data, including immunoblots, GSH and AA, were also analysed for statistical significance using a two-tailed unpaired Students t -test unless stated otherwise
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