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In phase III trials, these agents have demonstrated an average A1C decrease of about 0.5% when administered as monotherapy
Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
Furthermore, pooled analyses from CANVAS and CREDENCE reinforced the kidney protection of canagliflozin in DKD, irrespective of diabetes duration [49] or body mass index [50]
Arthur Christopoulos for advice on biased agonism
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