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As seen for the GIP receptor knockout mice, VLP-GIP efficiently reduced body weight gain in animals on a high-fat diet ( Two years later in 2010, GIP(4-42), GIP(5-42), GIP(7-42) and GIP(8-42) also proved to have functionally interesting antagonistic effects at the GIP receptor in vitro ( in vivo in mice reducing the effects of the native agonist, GIP(1-42)

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But they should not be expected to produce results comparable to prescription weight loss medications