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Given that NPC mutant models display de-regulated inter-organelle communication between LE/Lys and mitochondria, which correlates with compromised mitochondrial function in NPC disease [13, 89], the potential effects of the compounds identified in this study on mitochondrial function in NPC mutant models should be investigated in future studies
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Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography
Do not combine with another GLP-1 receptor agonist
Most changes are physiological responses to the metabolic improvements that GLP-1 produces and dont require intervention beyond observation
