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Rare systemic effects have also been observed in experimental models

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Edmonson, et al

[8] [18] Whilst nausea is a common class effect of GLP-1 receptor agonists, it's important to distinguish normal, expected nausea from symptoms that require medical attention

[68,69] This effect of GSH on skin pigmentation was reported half a century ago, with black human skin shown to exhibit lower levels of GSH than white skin