FoB were activated with 5 g/mL anti-IgM (Jackson Immunoresearch 715-006-020), 50 ng/mL CD40 ligand (Bio-techne 8230-CL-050) and 10 ng/mL IL-4 (Miltenyi Biotec 130-097-757)
Lieu C, Heymach J, Overman M, Tran H, Kopetz S
CCL3 promotes leukocyte recruitment via CCR5 signalling, which has been shown to inhibit long-term potentiation due to an attenuation of MAPK/CREB signalling and diminished hippocampal synaptic transmission, thereby contributing to cognitive impairment and neurodegeneration [204]
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Its ability to neutralise free radicals means it plays a vital role in preventing oxidative stress and cellular ageing [2]
Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barretts oesophagus: a systematic review and meta-analysis