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This inconsistency between these studies regarding HFD-induced antimicrobial peptide expression may be due to diet composition

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Cardiovascular Outcomes# LEADER Trial (Liraglutide)# The LEADER trial (Marso et al., NEJM 2016) enrolled 9,340 patients with type 2 diabetes and high cardiovascular risk

1.8 mg n = 30) without diabetes following 5 weeks treatment (titrated from 0.6 mg subcutaneously and increased in increments of 0.6 mg per week, up to end doses of 1.8 and 3.0 mg)

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Three days later, the accumulation levels of Hbs1, Pelo, Hsp70, P8, and Pns11 in the male reproductive organ were determined by western blot assay as described above