It blocks those opioid receptors, so the usual cascade gets muted
Yousef, Arwa Omar Al Khatib, Radwan Alnajjar, Faten Farouk, Amany Belal, Abdullah Yahya Abdullah Alzahrani, Marwa Sharaky Drug Development Research.2025;[Epub] CrossRef Prognostic Value of the Level of Urine Dipstick Proteinuria in Gastric Cancer in the Korean Population Yeo Ju Sohn, Sol Lee, Junghwa Kim, Insun Ryou, Eunjin Jeong, Jae-Hong Ryoo, Hyejin Chun Cancers.2025
Increased risk with higher serum POP levels has also been found for the development of cardiovascular disease, hypertension, insulin resistance, and the metabolic syndrome
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They noted that unmeasured lifestyle and dietary factors may have influenced results but concluded that clinicians should remain alert to reflux symptoms in patients starting GLP-1 RAs