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Even in the most recent years, such people underwent simple lab testing to exclude significant diseases, with serum B12 levels of just within the reference ranges often labelled as normal

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4 Primary end point: Mean change in BMI (%) from week 0 to week 68 3,4 Patients in both arms received instruction for reduced-calorie diet and increased physical activity All patients transitioned to a 7-week (weeks 68-75) off-treatment, lifestyle-therapy-only period

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