No slip
In this context, PRPs antioxidant capacity to reduce ROS and its ability to elevate cholesterol levels (both demonstrated in this study) make it a promising strategy for preventing or minimizing post-thaw degradation of sperm ion channels
Furthermore, in agreement with our data on ScGrx7 and PfGrx, Jao et al
The therapeutic index based upon animal studies is small
Future studies involving standardized animal experiments, prospective population-based studies, and clinical trials are required to further clarify their efficacy, safety, and clinical translational potential
Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial