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At this stage, claims about speed or degree of improvement should be viewed cautiously
Weight-loss medications rarely qualify for expedited review unless the patient has an acute comorbidity (e.g., uncontrolled diabetes with recent hospitalization)
[52] gave diet-induced obesity (DIO) mice daily GLP-1R/Gcg receptor (GcgR) double agonist (cotadutide), Lira, Gcg agonist (g1437), and Lira+g1437 respectively
Rapid weight loss can reduce mechanical stress on bones and sometimes decrease nutrient intake, both of which can contribute to lower bone density
M., Gomez Acosta, M., Bello, E
Polym J
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